Cell differentation, aging and cancer: The possible roles of superoxide and superoxide dismutases
نویسندگان
چکیده
منابع مشابه
Medical Hypotheses 6: 249-268, 1980 CELL DIFFERENTATION, AGING AND CANCER: THE POSSIBLE ROLES OF SUPEROXIDE AND SUPEROXIDE DISMUTASES
A unified theory of cell differentiation, aging, and cancer is discussed. All cells are hypothesized to originate from stem cells. These stem cells mature as they divide and eventually reach a fully differentiated cell, which cannot divide. Aging is caused by the loss of stem cells, either due to cell death or terminal differentiation, and by eventual death of fully differentiated cells. Both l...
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Reactive oxygen species (ROS) have important roles in normal physiology and diseases, particularly cancer. Under normal physiological conditions, they participate in redox reactions and serve as second messengers for regulatory functions. Owing to aberrant metabolism, cancer cells accumulate excessive ROS, thus requiring a robustly active antioxidant system to prevent cellular damage. Superoxid...
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Yuewei Sheng,† Isabel A. Abreu,*,‡,§ Diane E. Cabelli,* Michael J. Maroney,* Anne-Frances Miller,* Miguel Teixeira,*,‡ and Joan Selverstone Valentine*,†,∇ †Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States ‡Instituto de Tecnologia Química e Bioloǵica Antońio Xavier, Universidade Nova de Lisboa, Av. da Repub́lica, 2780-157...
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O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH.. SODs inhibit such HO. production by scavengingO2-, but Cu, ZnSODs, by virtue of a nonspecific peroxidase activity, may peroxidize spin trapping agents and thus give the appearance of catalyzing OH. production from H2O2. There is a glycosylate...
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The incidence of pancreatic cancer is increasing as the population ages but treatment advancements continue to lag far behind. The majority of pancreatic cancer patients have a K-ras oncogene mutation causing a shift in the redox state of the cell, favoring malignant proliferation. This mutation is believed to lead to nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and su...
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ژورنال
عنوان ژورنال: Medical Hypotheses
سال: 1980
ISSN: 0306-9877
DOI: 10.1016/0306-9877(80)90123-1